Glow Therapeutics: Helping Families Manage Sundowning in Dementia and Alzheimer's
Clinically Validated Photobiology

Harmoni:
Science meets simplicity

Every feature of Harmoni is engineered to address specific mechanisms of sundowning, translating decades of circadian chronoscience into a device families can use at home.

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Meet Harmoni

Beautifully designed to sit naturally in any home, Harmoni delivers clinical-grade light therapy without looking clinical.

Harmoni device on a coffee table

Addressing Sundowning at the Source

Harmoni targets the underlying circadian dysfunction that causes sundowning symptoms, not just masking them, but addressing the biological mechanisms directly.

Agitation & Restlessness

Dysregulated cortisol and circadian confusion create physiological stress

How Harmoni Helps

Precisely tuned blue light (470-480nm) re-entrains the SCN, stabilizing cortisol rhythms and reducing stress-induced agitation by up to 89%

Sleep Disturbances

Melatonin production is disrupted, leading to difficulty falling and staying asleep

How Harmoni Helps

Late morning and early afternoon light therapy strengthens circadian amplitude, promoting natural evening melatonin rise and extending sleep by an average of 2.5 hours

Confusion & Disorientation

SCN degeneration causes loss of temporal awareness. The brain can't tell what time of day it is

How Harmoni Helps

Daily light exposure provides powerful temporal cues to the damaged SCN, helping restore internal sense of time and reducing disorientation

Anxiety & Fear

Circadian disruption triggers inappropriate stress hormone release and emotional dysregulation

How Harmoni Helps

Circadian stabilisation normalises neuroendocrine function, reducing anxiety triggers. Red light (630nm) provides additional calming without disrupting sleep signals

The Science Behind Each Feature

Understanding how Harmoni's technical specifications translate to therapeutic benefit.

470-480nm blue + 630nm red light

Dual-Wavelength Precision

The Mechanism: Blue light maximally stimulates melanopsin, containing retinal ganglion cells (ipRGCs), the direct pathway to the SCN.

Clinical Benefit: Provides the strongest possible circadian entrainment signal to the damaged SCN, even when retinal pathways are compromised by dementia.

10am - 2pm Protocol

Circadian-Optimized Timing

The Mechanism: Light exposure in the mid-day biological phase advances the circadian rhythm, helping to prevent the evening desynchronisation that triggers sundowning.

Clinical Benefit: Targets the critical window when circadian intervention has maximum therapeutic effect, before symptoms emerge.

Adjustable 50-500 lux output

Calibrated Intensity Control

The Mechanism: Therapeutic light levels (>250 lux) achieve circadian entrainment without causing discomfort or glare.

Clinical Benefit: Delivers clinical-grade light therapy while remaining comfortable for extended use, accommodating individual sensitivity.

30-60 minute sessions

Extended Exposure Duration

The Mechanism: Circadian photoentrainment requires sustained light exposure to accumulate sufficient photon dose to the SCN.

Clinical Benefit: Ensures adequate light 'dose' reaches the circadian system, maximising therapeutic effect while remaining practical for daily use.

Harmoni Connected Care

Stay close, even when you can't be there

Harmoni is designed to support the person using it and the people who care about them. Through the Glow app, authorised family members and caregivers can check that Harmoni is being used, manage approved settings remotely and receive helpful information about changes in routine or the home environment.

Explore Harmoni Connected Care →

Connected Care for Peace of Mind

Harmoni is about more than light therapy. It is about keeping your loved one engaged, connected, and safe while supporting the entire family.

Alexa Integration

Built-in Alexa connectivity allows your loved one to listen to familiar music, audiobooks, or connect with family through voice calls during treatment sessions.

  • •Voice-activated music and radio (no buttons to press)
  • •Hands-free voice calls with family and friends
  • •Medication reminders and daily routines
  • •Comforting presence of a familiar voice assistant

Remote Family Monitoring

The smartphone app lets family members see when Harmoni is being used, track treatment adherence, and receive gentle notifications, providing peace of mind without intrusion.

  • •Real-time usage notifications (device turned on/off)
  • •Weekly adherence reports and trend tracking
  • •Low battery and maintenance alerts
  • •Optional check-in reminders for caregivers

Simple to Use, Powerful in Effect

Despite the sophisticated science, using Harmoni is straightforward — designed for caregivers and family members without technical expertise.

1

Position

Place Harmoni where your loved one spends time in late morning & early afternoon.

2

Time

Use between 10am-2pm daily, the critical window for circadian intervention.

3

Duration

30-60 minute sessions. Built-in timer tracks usage automatically.

4

Consistency

Daily use for 2-3 weeks to see full therapeutic effect.

Full Technical Specifications

Light Spectrum470-480nm blue, 630nm red LED
Intensity RangeAdjustable 50-500 lux
Photon Flux Density~10¹⁴ photons/cm²/s at max intensity
Treatment Duration30-60 minutes per session
Recommended Timing10:00-14:00 (10am-2pm)
ConnectivityAlexa built-in, Wi-Fi, Bluetooth
Power SourceRechargeable lithium battery (8hr life)
Form FactorPortable, lightweight (450g)
Safety CertificationsCE marked
Mobile AppiOS & Android compatible
Usage TrackingBuilt-in timer with memory
Warranty2 years full coverage + support

Reserve Your Harmoni — Launching Q4 2026

Be among the first to bring Harmoni into your home. Early supporters get exclusive pricing and priority shipping.

Reserve Your Spot
✦ Limited AvailabilitySecure your Harmoni device for just £49 — £200 balance due at launch Q4 2026.